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Cancer is the second leading cause of death in the United States. During 2000, an estimated 1,220,100 persons in the United States were expected to be diagnosed with cancer; 552,200 persons were expected to die from cancer. These estimates did not include most skin cancers, and new cases of skin cancer are estimated to exceed 1 million per year. One-half of new cases of cancer occur in people aged 65 years and over.

About 491,400 persons who get cancer in a given year, or 4 in 10 patients, are expected to be alive 5 years after diagnosis. When adjusted for normal life expectancy (accounting for factors such as dying of heart disease, injuries, and diseases of old age), a relative 5-year survival rate of 60 percent is seen for all cancers. This rate means that the chance of a person recently diagnosed with cancer being alive in 5 years is 60 percent of the chance of someone not diagnosed with cancer. Five-year relative survival rates commonly are used to monitor progress in the early detection and treatment of cancer and include persons who are living 5 years after diagnosis, whether in remission, disease free, or under treatment...

(Source: http://www.healthypeople.gov)

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Cardiovascular disease is the leading cause of death for both men and women in the U.S. Every year the number of people who die from cardiovascular diseases (CVD) worldwide is comparable to the current population of Australia: some 17 million. The main causes of death are coronary heart diseases and stroke. Medical therapies, drugs and rehabilitation cost health-care systems billions every year, and the lost productivity is an additional burden on the economy.

The risk factors leading to CVD are known: unhealthy living (smoking, excessive alcohol consumption, lack of exercise), hypertension, high levels of cholesterol, obesity and diabetes. More than 75 percent of all patients with type 2 diabetes will die as a result of heart infarction or stroke.

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Diabetes poses a significant public health challenge for the United States. Some 800,000 new cases are diagnosed each year, or 2,200 per day. The changing demographic patterns in the United States are expected to increase the number of people who are at risk for diabetes and who eventually develop the disease. Diabetes is a chronic disease that usually manifests itself as one of two major types: type 1, mainly occurring in children and adolescents 18 years and younger, in which the body does not produce insulin and thus insulin administration is required to sustain life; or type 2, occurring usually in adults over 30 years of age, in which the body's tissues become unable to use its own limited amount of insulin effectively.

The occurrence of diabetes, especially type 2 diabetes, as well as associated diabetes complications, is increasing in the United States. The number of persons with diabetes has increased steadily over the past decade; presently, 10.5 million persons have been diagnosed with diabetes, while 5.5 million persons are estimated to have the disease but are undiagnosed. (Source: www.healthypeople.gov)

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Approximately 20 percent of the U.S. population is affected by mental illness during a given year; no one is immune. Of all mental illnesses, depression is the most common disorder. More than 19 million adults in the United States suffer from depression. Major depression is the leading cause of disability and is the cause of more than two-thirds of suicides each year.

Impact of Depression

A person with a depressive disorder often is unable to fulfill the daily responsibilities of being a spouse, partner, or parent. The misunderstanding of mental illness and the associated stigmatization prevent many persons with depression from seeking professional help. Many people will be incapacitated for weeks or months because their depression goes untreated.

Depression is associated with other medical conditions, such as heart disease, cancer, and diabetes as well as anxiety and eating disorders. Depression also has been associated with alcohol and illicit drug abuse. An estimated 8 million persons aged 15 to 54 years had coexisting mental and substance abuse disorders within the past year.

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Long-term (chronic) effects of stress on the body

Chronic stress can be the result of many instances of acute stress or a life condition, such as a difficult job situation or chronic disease. In people with higher levels of chronic stress, the stress response stays on longer, contributing to their physical stress. Over time, chronic stress affects the cardiovascular system, the nervous system, and the immune system. For example, chronic stress can lead to high blood pressure and make you susceptible to infection and affect many diseases, such as depression, heart disease, and asthma. Chronic stress may also result in memory loss.

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Alzheimer's disease is a condition in which nerve cells in the brain die, making it difficult for the brain's signals to be transmitted properly. A person with Alzheimer's disease has problems with memory, judgment, and thinking, which makes it hard for the person to work or take part in day-to-day life. The death of the nerve cells occurs gradually over a period of years.

Late-onset Alzheimer's disease is the most common form of Alzheimer's disease, usually occurring after age 65. Late-onset Alzheimer's disease strikes almost half of all people over the age of 85 and may or may not be hereditary. Late-onset dementia is also called sporadic Alzheimer's disease.

As the population ages, the frequency of AD continues to increase. 10 % of people over age 65 and 50 % of those over 85 have AD. The number of individuals with AD is expected to be 14 million by the year 2050. In 1998, the annual cost for the care of patients with AD in the United States was approximately $40,000 per patient.

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Chronic Fatigue Syndrome (CFS) is described as a severe, debilitating fatigue, lasting at least six months (of new and definite onset), associated with at least 4 of the following symptoms: impaired memory or concentration, sore throat, lymphadenopathy, muscle pains, joint pains, new headaches, unrefreshing sleep, and malaise after exertion. Other medical and psychiatric conditions that can produce fatigue should be ruled out, including Lyme's disease. After demanding physical exercise, CFS patients show impaired cognitive processing.

Fibromyalgia Syndrome (FM) is a pain disorder associated with multiple tender points, sleep disturbances (insomnia and nonrestorative sleep) and fatigue. Hypothalamic dysfunction, immune dysfunction, and nutritional inadequacies can all cause or perpetuate this sometimes severe syndrome. CFS and FM may be opposite ends of the same disorder, with the emphasis on fatigue in CFS and pain in FM.